NCT04269278

Dexmedetomidine and Blood Coagulation

The Effect of Dexmedetomidine on Blood Coagulation: In Vitro, Volunteer Study Using Rotational Thromboelastometry

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 11 (actual)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.

Conditions

• Blood Coagulation Disorder

Interventions

Type	Name	Description
DRUG	0 ul of dexmedetomidine	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using dexmedetomidine
DRUG	0.25 ul of dexmedetomidine	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.25 ul) using dexmedetomidine
DRUG	0.5 ul of dexmedetomidine	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.5 ul) using dexmedetomidine
DRUG	0.75 ul of dexmedetomidine	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.75 ul) using dexmedetomidine

Timeline

• Start date: 2020-02-12
• Primary completion: 2020-12-30
• Completion: 2020-12-30
• First posted: 2020-02-13
• Last updated: 2021-07-02

Locations

1 site across 1 country: South Korea