NCT04269070

WorkWell: Work-based Activity and Metabolic Health

WorkWell: A Pre-clinical Pilot Study of Increased Standing and Light-intensity Physical Activity in Prediabetic Sedentary Office Workers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Arizona State University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study will test whether a range of pre-clinical cardiometabolic biomarkers can be improved via regular intervals of standing and light-intensity physical activity in real-world office environments.

Detailed description

This pilot study is being conducted to determine whether a range of pre-clinical cardiometabolic biomarkers (measured via gut microbiome, blood draw) can be improved via regular intervals of standing and light-intensity physical activity (i.e., leisurely walking) in real-world office environments. This trial is meant to generate pilot data which will lead to additional clinical trials. Primary Hypothesis: Increasing both standing and light-intensity physical activity will improve biomarkers of metabolic function, as measured by blood metabolites and differential abundance of gut microbiome composition, compared to a control condition of normal workplace behavior.

Conditions

• PreDiabetes
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Standing condition	Participants will be asked to stand an additional 6 minutes per hour above their median standing time from the observed time in the usual behavior condition.
BEHAVIORAL	Light physical activity (LPA) condition	Participants will be asked to perform 6 additional minutes per hour above their median LPA time from the observed time in the usual behavior condition.
BEHAVIORAL	Usual behavior condition	Participants will be asked to perform their normal work activities in their normal work environment for one week. There will be no modifications to their work environment or instructions given of what activities to partake in. This period will be used to understand their normal standing and LPA behaviors to determine the personalized changes to their standing and LPA behaviors in the other conditions.

Timeline

• Start date: 2021-03-25
• Primary completion: 2023-04-30
• Completion: 2023-04-30
• First posted: 2020-02-13
• Last updated: 2023-05-10

Locations

1 site across 1 country: United States