NCT04268563

Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

Comparing the Therapeutic Effect of Sitagliptin/Metformin and Metformin on Biochemical Factors and Expression of GDF-9 and BMP-15 Genes in Patients With Classic PCOS Undergoing Intra-cytoplasmic Sperm Injection (ICSI)

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Shahid Beheshti University of Medical Sciences · Academic / Other
• Sex: Female
• Age: 25 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).

Detailed description

This study was conducted in Infertility clinic of Mahdiyeh Educational Hospital, Tehran. Patients in the four groups receive the drug 2 months before the start of the ovulation cycle, and treatment will continue until the day of the oocyte aspiration. The drug provide by midwife to patients and both patient and physician blind to the treatment regimen. The participants randomly divide into four groups.The ovulation induction stimulate with GnRh antagonist.

Conditions

• Polycystic Ovary Syndrome
• Infertility
• ART

Interventions

Type	Name	Description
DRUG	placebo	Oral rehydration solution
DRUG	metformin	metformin tablet
DRUG	Sitagliptin	Sitagliptin tablet
DRUG	Sitagliptin/metformin	Sitagliptin/metformin tablet

Timeline

• Start date: 2020-01-10
• Primary completion: 2021-07-19
• Completion: 2021-07-30
• First posted: 2020-02-13
• Last updated: 2021-03-22

Locations

1 site across 1 country: Iran