Trials / Completed
CompletedNCT04266587
ACTH Stability on Whole Blood
Adrenocorticotropic Hormone Stability on Whole Blood
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 10 (actual)
- Sponsor
- University Hospital, Rouen · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
ACTH is a peptide secreted by pituitary gland and plays an important role in regulating cortisol secretion. ACTH is determined in plasma by immunoassays using specific antibodies. Its determination is difficult because of instability in whole blood. Several factors which influence ACTH stability in blood before analysis have been identified: temperature, hemolysis, time to centrifugation and presence of protease inhibitors. Published results on ACTH whole blood stability seem contradictory. The objective of this study is to evaluate the effect of aprotinin in 10 healthy volunteers. ACTH measurements will be performed on cobas e602 (Roche Diagnostics, Mannheim, Germany).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Blood sampling | blood sampling is done on healthy volunteers |
Timeline
- Start date
- 2021-11-18
- Primary completion
- 2021-11-18
- Completion
- 2021-11-18
- First posted
- 2020-02-12
- Last updated
- 2026-02-10
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04266587. Inclusion in this directory is not an endorsement.