NCT04265001

Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis.

Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

This study was conducted to estimate the hypothesis that the topical hyaluronic acid mouthwash have no role in the treatment of recurrent aphthous stomatitis

Detailed description

Recurrent aphthous stomatitis (RAS) is a common and widely recognized disorder involving the oral mucosa. It occurs typically as a single or multiple well-defined painful self-limiting ulcerative lesions influencing the nonkeratinized oral mucous membrane surrounded by red halo. The prevalence of RAS is up to 25% in the world population, with recurrence rate of 50% every 3 mouths. The exact cause of RAS is uncertain, and accordingly numerous components are as yet being implicated such as genetic, hormonal, traumatic, nutritional, allergic, immunological, and psychological factors.

Conditions

• Recurrent Aphthous Stomatitis

Interventions

Type	Name	Description
DRUG	Hyaluronic acid in the form of hyaluronan sodium 25 mg/100 ml as a mouthwash	Topical mouthwash used three times daily for one week and patients were not allowed to eat or drink for one hour after rinsing.

Timeline

• Start date: 2019-11-01
• Primary completion: 2020-01-20
• Completion: 2020-01-20
• First posted: 2020-02-11
• Last updated: 2020-02-11

Locations

1 site across 1 country: Egypt