NCT04261803

FH Detection in Children by Salivary Test

Familial Hypercholesterolemia Non Invasive Detection in Children by Salivary Test

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 2 Years – 17 Years
• Healthy volunteers: Accepted

Summary

Familial Hypercholesterolemia is a common cause of premature coronary heart disease, it is present in 1 per 500 to 1 per 250 people of the general population. Studies on families of Hypercholesterolemia have shown that children with Hypercholesterolemia have a major increase in risk of coronary heart disease after the age of 20. The difference between Hypercholesterolemia and normal children in their atherogenic profil begin at the age of Nowadays , systematic screening techniques are not well implemented whereas their are clear World health organization guidelines. International studies show treatment must be initiated early as at the age of eight years old. In pediatry, Parents can be reluctant to practice blood test on their children. In order to allow more patients to be diagnosed and treated early enough to prevent major complications we need to find an non invasive test. The main objective is to define the level of detection of cholesterol in saliva with two enzymatic tests. Furthermore we aim to evaluate the performance of salivary detection of cholesterol in children.

Conditions

• Hyperlipoproteinemia Type II

Interventions

Type	Name	Description
BIOLOGICAL	salivary sample	spit of saliva in a tube
BIOLOGICAL	blood test	2millilitter blood test

Timeline

• Start date: 2020-02-18
• Primary completion: 2020-08-26
• Completion: 2020-08-26
• First posted: 2020-02-10
• Last updated: 2020-09-07

Locations

1 site across 1 country: France