NCT04260724

Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

Prospective, Randomized, Evaluator-blind, Single Center Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 55 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The investigators will compare cognitition, mood (depression), ADL, and brain structural and functional MRI before and after 4-week transcranial magnetic stimulation in patients with mild to moderate Alzheimer's disease. The investigators also compare the change of cognitition, mood (depression), ADL, and brain structural and functional MRI between TMS group and sham coil group.

Detailed description

Each 16 patients will be allocated to TMS group and sham coil group. Before TMS/sham coil stimulation, the investigators will take fMRI of each patient, and figure out which focus has strongest connectivity to hippocampus among lateral parietal regions of the brain. The investigators will fix the TSM transduced and apply accurate TMS stimulation to the focus using personalized frames. The investigators will make the frame using 3D printing technology. After 4 week- TMS stimulation, the investigators will compare cognitition, mood (depression), ADL, and brain structural and functional MRI beween baseline and after intervention. The investigators also compare the change of cognitition, mood (depression), ADL, and brain structural and functional MRI between TMS group and sham coil group.

Conditions

• Mild to Moderate Alzheimer Disease

Interventions

Type	Name	Description
DEVICE	TMS	* stimulation intensity : motor threshold 100% * stimulation frequency : 1600 pulses for 20 minutes * stimulation duration :for four weaks, 20 minutes/day, 5 days per week (Monday - Friday )
DEVICE	sham coil stimulation	no stimulation Although the sound from device during stimulation is similar, no stimulation is applied.

Timeline

• Start date: 2020-02-07
• Primary completion: 2021-02-07
• Completion: 2022-02-07
• First posted: 2020-02-07
• Last updated: 2020-02-07

Locations

1 site across 1 country: South Korea