NCT04260516

The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 3 Years – 14 Years
• Healthy volunteers: Not accepted

Summary

The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study duration

Detailed description

N-acetylcysteine( NAC) is a widely used mucolytic drug and several studies had reported its efficacy as anti oxidant. Patients with thalassemia major are at great risk for oxidative stress due to excess of b-globin chains and iron overload. In this study the investigators compared the effect of NAC on oxidative status , pretransfusion hemoglobin levels and iron overload in thalassemia patients before and after treatment with NAC for 3 months and with that of patients who served as controls.

Conditions

• Thalassemia Major

Interventions

Type	Name	Description
DRUG	N-acetyl cysteine	Mucolytic and antioxidant drug

Timeline

• Start date: 2019-06-03
• Primary completion: 2019-12-03
• Completion: 2019-12-30
• First posted: 2020-02-07
• Last updated: 2020-02-07

Locations

1 site across 1 country: Egypt