NCT04259398

Anesthesia and Cancer Study: Colon Cancer

The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 797 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 19 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Detailed description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Conditions

• Cancer of Colon
• Anesthesia

Interventions

Type	Name	Description
DRUG	Propofol	propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia
DRUG	Sevoflurane	sevoflurane is administered for induction and maintenance of anesthesia

Timeline

• Start date: 2020-02-18
• Primary completion: 2028-05-03
• Completion: 2028-05-03
• First posted: 2020-02-06
• Last updated: 2023-11-22

Locations

2 sites across 1 country: South Korea