Trials / Completed
CompletedNCT04259372
Analysis of T Cell Metabolism in Acute Myeloid Leukemia Patients
Analysis of T Cell Metabolism and Immune Phenotype During the Course of Acute Myeloid Leukemia
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 77 (actual)
- Sponsor
- University of Freiburg · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The objective of this study was to analyze the T cell metabolism and immune phenotype in AML patients during the course of the disease before and after allo-HCT.
Detailed description
Patients who experience relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (allo-HCT) have a dismal prognosis. Infusion of donor T cells can induce graft-versus-leukemia (GVL) effects, indicating the importance of intact T cell function for leukemia control. Recent studies have shown the importance of metabolic fitness for an effective T cell response. In this study we have analyzed the T cell metabolism and immune phenotype in AML patients at different time points before and after allo-HCT.
Conditions
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2019-12-31
- Completion
- 2019-12-31
- First posted
- 2020-02-06
- Last updated
- 2020-02-06
Source: ClinicalTrials.gov record NCT04259372. Inclusion in this directory is not an endorsement.