NCT04258553

Thiol Disulfide Balance in Cervix Cancer

Evaluation of Thiol Disulfide Balance in Cervix Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 123 (actual)
• Sponsor: Muğla Sıtkı Koçman University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this research is to evaluate thiol-disulfide balance in cervix cancer patients

Detailed description

To date various oxidative stress parameters were studied in patients with cervix cancer, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu (1). References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.

Conditions

• Cervix Cancer
• Oxidative Stress

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Disulphide(μmol/L)	Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with spectrophotometry
DIAGNOSTIC_TEST	Total Oxidant Capacity(μmolH2O2Equiv/L)	Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with spectrophotometry
DIAGNOSTIC_TEST	Ischemia Modified Albumin(IU/mL)	The serum Ischemia Modified Albumin concentrations were measured as described by Bar-Or et al. (Bar-Or et al. 2000).

Timeline

• Start date: 2018-09-01
• Primary completion: 2020-01-20
• Completion: 2020-02-04
• First posted: 2020-02-06
• Last updated: 2020-04-30

Locations

1 site across 1 country: Turkey (Türkiye)