NCT04257240

Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury

Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 230 (actual)
• Sponsor: Aretaieion University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

Detailed description

One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. These individuals were retrospectively matched to 112 counterparts, who underwent liver surgery applying inflow and outflow vascular clamping only of the segment harboring the tumor, sparing the liver remnant from any I/R injury (control group). The two cohorts were compared regarding recurrence-free survival and overall survival.

Conditions

• Ischemic Reperfusion Injury
• Liver Injury
• Cancer Recurrence
• Malignancy
• Liver Cancer

Interventions

Type	Name	Description
PROCEDURE	selective hepatic vascular exclusion	major hepatectomy with vascular control of blood inflow and outflow of the whole liver
PROCEDURE	semielective hepatic vascular exclusion	major liver resection by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor

Timeline

• Start date: 2000-01-01
• Primary completion: 2012-12-31
• Completion: 2012-12-31
• First posted: 2020-02-05
• Last updated: 2020-02-05