NCT04255992

Short Term Cardiovascular Effects and Oxidative Status of Calcium and Vitamin D Supplementation of Postmenopausal Hypertensive Blacks Women

Short Term Cardiovascular Effects and Oxidative Status of Calcium and Vitamin D Supplementation of Postmenopausal Hypertensive Blacks Women in Sub Saharan Africa

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Yaounde Central Hospital · Other Government
• Sex: Female
• Age: 30 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study aims to determine the effect of calcium and vitamin D supplementation on oxidative status and blood pressure profile of postmenopausal patients with high blood pressure in Yaoundé, Cameroon. This study is a double-arm, double-blind, randomized and parallel clinical trial conducted at the Yaoundé Central Hospital

Detailed description

Aim: to determine and compare the short term effect of calcium and vitamin D supplementation on oxidative status and blood pressure profile of postmenopausal patients with high blood pressure in Yaoundé, Cameroon. Method: A double-arm, double-blind, randomized and parallel clinical trial conducted at the Yaoundé Central Hospital. Postmenopausal hypertensive blacks women who are taking taking antihypertensives drugs since 12 months,without diabetes mellitus or any inflammatory disease or hypercalcemia, are randomize into 2 groups. Depending on the group, the intervention consisted of the administration of Calcium 1000 mg daily or Vitamin D/Calcium 1000 mg/800 UI daily for 08 weeks. The endpoints were the nycthemeral blood pressure profile, pro oxidant marker (malondialdehyde) and anti-oxidant marker (Ferric reducing antioxidant). Progress: Recruitment for this study was completed in May 2019 with 22 patients.

Conditions

• Hypertension
• Postmenopausal Disorder

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Calcium Arm	1000 mg Calcium tablet / day will be added to the usual treatment for each patient for a period of 8 weeks.
DIETARY_SUPPLEMENT	Vitamin D/Calcium	1000 mg/800UI of the association Vitamin D/Calcium tablet / day will be added to the usual treatment for each patient for a period of 8 weeks.

Timeline

• Start date: 2018-11-01
• Primary completion: 2019-05-15
• Completion: 2019-05-15
• First posted: 2020-02-05
• Last updated: 2020-02-05

Locations

1 site across 1 country: Cameroon