NCT04255823

Efficacy of a Multi-faceted Intervention to Deprescribe Proton Pump Inhibitors (PPI) in Primary Care: a Population-based, Pragmatic, Cluster-randomized Controlled Trial.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34,000 (actual)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Deprescribing is defined as "the process of withdrawal of an inappropriate medication, supervised by a health care professional with the goal of managing the polypharmacy and improving outcomes". Inappropriate use of proton pump inhibitors (PPI) is associated with severe adverse drug reactions and a major economic impact. Deprescribing should be considered when inappropriate prescription of PPI is identified. DeprescrIPP is a pragmatic population-based cluster-randomized trial conducted in primary care. It will assess the efficacy and effectiveness of a multi-faceted intervention (on patients and general practitioners) to deprescribe PPI.

Conditions

• Proton Pump Inhibitors
• Deprescription

Interventions

Type	Name	Description
OTHER	General practitioner and Patient receive informations related to PPI deprescribing.	General practitioner will receive a sensibilization and an algorithm related to PPI deprescribing. Their patients will receive any informations (patient information material on PPI deprescribing)
OTHER	Only General practitioner receive informations related to PPI deprescribing.	General practitioner will receive the sensibilization and an algorithm related to PPI deprescribing. Their patients will not receive any informations.

Timeline

• Start date: 2020-09-29
• Primary completion: 2021-12-15
• Completion: 2021-12-15
• First posted: 2020-02-05
• Last updated: 2024-04-22

Locations

1 site across 1 country: France