NCT04254731

Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals

The Study of Potential Normalization of Cardiac Rhythm Following Drug Exchange From Chimeric Methadone to Active Methadone

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals

Detailed description

Racemic methadone may prolong the QTc interval, which is associated with fatal arrhythmias. In vitro studies have shown that R-methadone has less inhibitory effect than S-methadone on the voltage-gated potassium channel current, and is thus thought to have less effect on the QTc interval. The investigators hypothesized that switching from racemic to R-methadone would reduce the methadone serum concentration and also its effect on the QTc interval.

Conditions

• Adverse Drug Effect
• Drug Effect
• Heart Arrhythmia

Interventions

Type	Name	Description
DRUG	Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)

Timeline

• Start date: 2015-05-07
• Primary completion: 2018-06-27
• Completion: 2024-07-30
• First posted: 2020-02-05
• Last updated: 2024-04-03

Locations

3 sites across 1 country: Norway