Trials / Terminated
TerminatedNCT04250168
Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response
Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response to Detect Intercurring Bloodstream Infections and Inform Appropriate Antibiotic Treatment
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 43 (actual)
- Sponsor
- Institute of Tropical Medicine, Belgium · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Despite access to experimental Ebola Virus Disease (EVD)-specific treatments, about 30% of patients still die in the Ebola Treatment Centers (ETC) in DRC. There is limited study done about the potential contribution of bacterial co-infections (in particular bloodstream infections) to this adverse outcome, as blood cultures were so far rarely available in epidemic areas. Findings from patients treated in Europe and the USA, and case discussions in the field call for further investigation. Building further on an ongoing microbiological surveillance project of ITM and INRB in DRC, we are able to set up a research project which will pilot in a standardized manner clinical bacteriology tools (bacterial blood cultures, biomarkers as CRP, procalcitonin and white blood cell differential count, and clinical early warning scores) to study bacterial bloodstream infection in EVD patients in the N-Kivu/Ituri outbreak. This project will add evidence on 1) frequency, causative pathogen and antibiotic resistance profiles of bacterial bloodstream infections, as well as 2) the predictive value of biomarkers and early warning scores, in EVD patients at different timepoints during hospitalization in an ETC in DRC. The results will inform appropriate antibiotic treatment in an EVD setting and improve patient outcomes.
Conditions
Timeline
- Start date
- 2019-11-11
- Primary completion
- 2020-05-15
- Completion
- 2020-06-23
- First posted
- 2020-01-31
- Last updated
- 2020-08-12
Locations
2 sites across 1 country: Democratic Republic of the Congo
Source: ClinicalTrials.gov record NCT04250168. Inclusion in this directory is not an endorsement.