Trials / Completed
CompletedNCT04248426
A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 88 (actual)
- Sponsor
- Antios Therapeutics, Inc · Industry
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
This is a double-blinded, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics, and antiviral activity in both healthy volunteers and volunteers with chronic hepatitis B virus infection. Healthy volunteers will be administered either a single oral dose or multiple oral doses of ATI-2173 and assessed for safety and tolerability including blood tests to show how the body metabolizes and eliminates the investigational drug. Volunteers with a diagnosis of chronic hepatitis B virus infection will be administered multiple oral doses of ATI-2173 and assessed for safety and tolerability including blood tests to show how the body metabolizes and eliminates the investigational drug as well as how the drug effects the virus infection.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | ATI-2173 | ATI-2173 is a liver-targeted phosphoramidate prodrug of clevudine designed to enhance anti-HBV activity while decreasing systemic exposure to clevudine. It will be dosed as a capsule by mouth. |
| DRUG | ATI-2173 Placebo | ATI-2173 Placebo is used as an inactive comparator to ATI-2173. It will be dosed as a capsule by mouth. |
Timeline
- Start date
- 2020-02-05
- Primary completion
- 2021-05-18
- Completion
- 2021-05-18
- First posted
- 2020-01-30
- Last updated
- 2021-08-19
Locations
3 sites across 3 countries: Canada, Moldova, Ukraine
Source: ClinicalTrials.gov record NCT04248426. Inclusion in this directory is not an endorsement.