NCT04245072

Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis

Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: The Filatov Institute of Eye Diseases and Tissue Therapy · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.

Detailed description

The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis. This study is planned as a follow-up. Patients with central chorioretinitis included in it will receive antiangiogenic therapy in accordance with the approved indications for use indicated in the instructions for the use of drugs in Ukraine. The treatment proposed in this study is based on the world experience and scientific developments of the Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine ". Therefore, it is expected that the benefit / risk ratio in relation to the participation in this study should not be different from that described in the scientific literature and the benefits outweigh the risk. It is known that the absence of treatment in these diseases leads to an irreparable loss of central vision.

Conditions

• Chorioretinitis

Interventions

Type	Name	Description
PROCEDURE	Intravitreal injection	Intravitreal injection of Aflibercept 2 mg (0.05 ml) or Ranibizumab 0.5 mg (0.05 ml) to the regimen pro re nata.
DIAGNOSTIC_TEST	Fluorescent angiography	Ophthalmic examination
DIAGNOSTIC_TEST	Visometry	Ophthalmic examination
DIAGNOSTIC_TEST	Refractometry	Ophthalmic examination
DIAGNOSTIC_TEST	Slit lamp examination	Ophthalmic examination
DIAGNOSTIC_TEST	Ophthalmoscopy	Ophthalmic examination
DIAGNOSTIC_TEST	OKT	Ophthalmic examination

Timeline

• Start date: 2018-03-27
• Primary completion: 2021-12-31
• Completion: 2022-01-31
• First posted: 2020-01-28
• Last updated: 2021-02-03

Locations

3 sites across 1 country: Ukraine