NCT04242524

The Impact of Bariatric Surgery on Adipocyte Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: Female
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand how daily rhythms of behavior affect the expression of genes in fat cells, and how these daily cycles affect the way fat cells respond to insulin (a hormone that controls blood sugar levels) before and after bariatric surgery.

Detailed description

Bariatric surgery as a means of weight loss has become increasingly popular over the last 10-15 years. In addition to promoting weight loss, bariatric surgery has become increasingly recognized for use in the management of diabetes. Recent studies have indicated that bariatric surgery can result in a marked improvement in insulin sensitivity before long term weight loss is attained. The goal of this project is to delineate the changes in the insulin responsiveness of subcutaneous adipocytes obtained by needle biopsy 2 weeks prior to surgery vs. 12 weeks after bariatric surgery, which could account for improvements in overall insulin sensitivity seen before any long-term sustained weight loss has occurred. The investigators will also examine gene expression in adipocytes (fat cells).

Conditions

• Metabolic Syndrome
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Circadian Clock Alignment	Use timed lights and meals to align the circadian clock
BEHAVIORAL	Circadian Clock Control	No circadian clock alignment

Timeline

• Start date: 2015-03-26
• Primary completion: 2025-12-15
• Completion: 2025-12-15
• First posted: 2020-01-27
• Last updated: 2026-02-13

Locations

1 site across 1 country: United States