NCT04241640

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy Pain Management and the Improvement of Enhanced Recovery After Surgery (ERAS): a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.

Conditions

• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Nefopam 20 MG/ML	Nefopam group nefopam 20 mg during surgery and follow by 80 mg in 24 hours postoperative
DRUG	Placebo	Placebo

Timeline

• Start date: 2020-09-01
• Primary completion: 2022-08-01
• Completion: 2023-03-01
• First posted: 2020-01-27
• Last updated: 2024-11-20

Locations

1 site across 1 country: Thailand