Trials / Unknown
UnknownNCT04239794
The Influence of Type of Anesthesia on Postoperative Pain
The Influence of Type of Anesthesia on Postoperative Pain After Laparoscopic Colorectal Cancer Surgery: Multi-center Prospective Randomized Controlled Study
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 468 (actual)
- Sponsor
- Seoul National University Hospital · Academic / Other
- Sex
- All
- Age
- 19 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.
Detailed description
Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Propofol | General anesthesia during the laparoscopic colorectal surgery is achieved by using a target-controlled intravenous infusion of propofol. |
| DRUG | Sevoflurane | General anesthesia during the laparoscopic colorectal surgery is achieved by using an inhalation agent (Sevoflurane). |
Timeline
- Start date
- 2020-02-20
- Primary completion
- 2023-12-19
- Completion
- 2024-01-31
- First posted
- 2020-01-27
- Last updated
- 2023-12-22
Locations
3 sites across 1 country: South Korea
Source: ClinicalTrials.gov record NCT04239794. Inclusion in this directory is not an endorsement.