NCT04238611

Minimally-Invasive Realtime Assessment of Continuous Lactate in Exercise

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Lactate is a compound produced as a by-product of glycolysis. The increase in lactate concentration can result from a variety of causes, such as during anaerobic metabolism in exercise or haemodynamic shock in conditions such as sepsis. The study will aim to validate a novel microneedle-based minimally invasive device for the continuous measurement of lactate during exercise.

Detailed description

Lactate is a compound produced as a by-product of glycolysis. The increase in lactate concentration can result from a variety of causes, such as during anaerobic metabolism in exercise. The measurement of blood lactate during exercise has been routinely used to determine individual anaerobic thresholds, and optimise training in athletes. The measurement of the lactate trend requires multiple blood tests, and this can be uncomfortable. The need for repeated procedures may therefore restrict the full utility of the biomarker. Although point-of-care lactate measurements are possible, the barriers to initiating testing may also limit its role in clinical decision-making. The aim of the study is the validation of the microneedle-based lactate biosensor for real-time continuous lactate measurement in healthy volunteers during exercise as proof-of-concept.

Conditions

• Exercise
• Lactate

Interventions

Type	Name	Description
DEVICE	Microneedle	Lactate microneedle applied on the skin of participant
DIAGNOSTIC_TEST	Blood lactate measurement	Serum lactate testing through conventional laboratory methods
OTHER	Exercise regimen	Standardised aerobic exercise regimen

Timeline

• Start date: 2021-03-01
• Primary completion: 2021-09-01
• Completion: 2022-03-01
• First posted: 2020-01-23
• Last updated: 2021-08-26

Locations

1 site across 1 country: United Kingdom