NCT04234217

Mechanisms of Prediabetic States in Sleep Apnea

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to better understand how sleep apnea contributes to the development of diabetes.

Detailed description

Substantial evidence indicates that obstructive sleep apnea (OSA) is associated with impaired glucose metabolism, however, metabolic mechanisms underlying this association remain unclear. This mechanistic study will determine systemic and cellular metabolic pathways that contribute to impaired glucose metabolism in obstructive sleep apnea (OSA). Understanding of how obstructive sleep apnea (OSA) affects glucose metabolism may help identify novel targets for risk prediction and/or treatment of metabolic impairments beyond continuous positive airway pressure (CPAP). Obstructive sleep apnea (OSA) patients with prediabetes will be studied under three in-laboratory conditions in a randomized cross-over design: untreated condition (obstructive sleep apnea), treated condition (continuous positive airway pressure), untreated but pharmacologically suppressed lipolysis condition (Niacin). The investigator will perform whole body and cellular assessments under each study condition.

Conditions

• Sleep Apnea
• Pre-diabetes

Interventions

Type	Name	Description
DEVICE	Continuous positive airway pressure	Continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA)
OTHER	Niacin	Suppression of lipolysis by niacin infusion

Timeline

• Start date: 2019-11-26
• Primary completion: 2026-07-15
• Completion: 2026-07-15
• First posted: 2020-01-21
• Last updated: 2025-11-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study