NCT04233606

Influence of Osmotic Stimulation of Vasopressin on Autonomic Function

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of North Carolina, Greensboro · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The regulation of total body water that defines human hydration status is a complex and dynamic process. Current methods of assessing hydration status (e.g. hematologic and urinary analyses) lack the ability to track changes in hydration status in real-time due to whole-body homeostatic physiologic processes required to maintain central pressure and cardiovascular function. This project will address this problem by assessing the relationship between autonomic function (measured using heart rate variability), a brain-derived process that regulates cardiovascular function, and changes in the hydration-mediated hormone vasopressin.

Conditions

• Water Stress
• Body Water Dehydration

Interventions

Type	Name	Description
OTHER	Hypertonic Saline	Infusion of hypertonic saline to induce an osmotic secretion of the hormone vasopressin
OTHER	Normal Saline	Infusion of normal saline to inhibit the secretion of the hormone vasopressin

Timeline

• Start date: 2023-11-01
• Primary completion: 2024-07-01
• Completion: 2024-07-01
• First posted: 2020-01-18
• Last updated: 2023-11-13

Locations

1 site across 1 country: United States