NCT04233268

RASCALS: Rapid Assay for Sick Children With Acute Lung Infection Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: Cambridge University Hospitals NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 0 Months – 16 Years
• Healthy volunteers: Not accepted

Summary

Lower Respiratory Tract infections are a common cause of admission to the intensive care unit. Children routinely receive antibiotics until the tests confirm whether the infection is bacterial or viral. The exclusion of bacterial infection may take 48 hours or longer for culture tests on biological samples to be completed. In many cases, the results may be inconclusive or negative if the patient has already received antibiotics prior to the sample being taken. A rapid assay to detect the most likely cause of infection could improve the speed with which antibiotic therapy is rationalised or curtailed. This study aims to assess whether a new genetic testing kit which can identify the presence of bacteria and viruses within hours rather than days is a feasible tool in improving antibiotic prescribing and rationalisation of therapy in critically ill children with suspected lower respiratory tract infection.

Conditions

• Lower Respiratory Tract Infection
• Ventilator Associated Pneumonia
• COVID19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Rapid Pathogen Detection	Rapid assays for pathogen detection on bronchoalveolar lavage fluid

Timeline

• Start date: 2020-06-06
• Primary completion: 2023-02-28
• Completion: 2025-02-28
• First posted: 2020-01-18
• Last updated: 2021-10-20

Locations

1 site across 1 country: United Kingdom