Trials / Unknown
UnknownNCT04232787
Southeast Asian Brugada Syndrome Cohort
Discovering the Genetic Causes of Brugada Syndrome in Thais and Southeast Asian Population
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 750 (estimated)
- Sponsor
- Chulalongkorn University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
Brugada syndrome (BrS) is the leading cause of sudden death in young Asian adults including Thailand. This syndrome may be hereditary and involve mutations in certain genes. Aim of the study is to identify the relationship between genetic variants and the diagnosis/clinical severity of patients with BrS.
Detailed description
This cohort study recruits BrS patients with confirmed Brugada type 1 ECG and healthy volunteers in Thailand. Data collection consists of demographic, clinical data, ECG and blood sample for genetic studies. Genotyping was done by whole genome sequencing and SNP array then compared between cases and controls. Each BrS patient will be followed up prospectively for symptoms and AICD shock. Subsequently, the study will analyze relationship between genetic variants and clinical data against clinical severity of BrS patients.
Conditions
Timeline
- Start date
- 2016-01-28
- Primary completion
- 2021-01-01
- Completion
- 2023-01-01
- First posted
- 2020-01-18
- Last updated
- 2020-01-18
Locations
11 sites across 1 country: Thailand
Source: ClinicalTrials.gov record NCT04232787. Inclusion in this directory is not an endorsement.