NCT04225481

Evaluation of Enhanced Therapeutic Effect of Adipose Stromal Vascular Fraction Added With Human Platelet Lysate in Treatment of Osteoarthritis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 27 (estimated)
• Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Osteoarthritis (OA) is a highly progressive and debilitating joint disease. Recently, it was demonstrated the existence of an important link between OA inflammation and progression of structural changes. Therapy with intra-articular injection of stromal vascular fraction (SVF) holds great promises and its efficacy could be further augmented with the addition of biological adjuvants. In the present project, we aim at demonstrating that human platelet lysate (HPL) increases the intrinsic beneficial properties of SVF on cartilage regeneration and joint environment. Moreover, we want to verify if SVF-conditioned medium (CM) obtained from SVF primed with HPL yields comparable or superior outcomes than whole SVF.

Conditions

• Assessment of the Trophic and Anti-inflammatory Effect of SVF Added With HPL

Interventions

Type	Name	Description
OTHER	isolation of waste material and culturing with different supplement culture media	isolation of waste material and culturing with different supplement culture media

Timeline

• Start date: 2020-01-01
• Primary completion: 2021-07-01
• Completion: 2022-07-01
• First posted: 2020-01-13
• Last updated: 2020-01-13