NCT04224181

Inflammation and Cardiovascular Health in Women

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 62 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: Female
• Age: 40 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI). Among women with HIV (WHIV), heightened systemic immune activation and inflammation persist, even when HIV infection is well-treated with contemporary antiretroviral therapeutic regimens. Moreover, WHIV in high-resource regions face a three-fold increased risk of myocardial infarction as compared with matched non-HIV-infected women. The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women.

Detailed description

The goals of this study are to better understand ways in which HIV infection-incited systemic immune activation and inflammation augment MI risk among women. To this end, WHIV and non-HIV-infected women will undergo structural and functional cardiovascular imaging studies (Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography) as well as vascular, metabolic/hormonal, and immune phenotyping. Measures of immune activation, arterial inflammation, and cardiovascular pathology will be compared between groups and interrelationships between these parameters will be assessed among WHIV.

Conditions

• HIV/AIDS
• Myocardial Infarction

Interventions

Type	Name	Description
RADIATION	Cardiac PET	A scan examining blood flow to the heart
RADIATION	99mTc-tilmanocept SPECT/CT	A scan to look at inflammation in the arteries
RADIATION	Contrast Enhanced Coronary and Aortic Computed Tomography Angiography	A scan of the heart and surrounding blood vessels

Timeline

• Start date: 2020-02-03
• Primary completion: 2023-11-09
• Completion: 2023-11-09
• First posted: 2020-01-13
• Last updated: 2024-02-20

Locations

1 site across 1 country: United States