NCT04223531

The Natriuretic Peptide Response to Saline Infusion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The primary objective is to evaluate the overarching hypothesis that obese and black individuals have relatively lower circulating natriuretic peptide levels compared with lean and white individuals. Conventional clinical assays for measurement of circulating natriuretic peptides display substantial overlap, precluding determination of the basis of the relative natriuretic peptide deficiency previously observed in these groups. We will study lean or obese, black or white, healthy adult subjects with intravenous (IV) saline infusion as a stimulus for natriuretic peptide production and release. We will measure circulating levels of natriuretic peptide isoforms using mass spectrometry that allows the specific identification of proBNP 1-108 and its cleavage product BNP 1-32.

Conditions

• Obesity

Interventions

Type	Name	Description
DRUG	Normal Saline 0.9% Infusion Solution Bag	Participants will receive a normal saline infusion at a rate of 10ml per unit of body surface area per minute for 120 minutes.

Timeline

• Start date: 2020-10-26
• Primary completion: 2022-06-17
• Completion: 2022-06-17
• First posted: 2020-01-10
• Last updated: 2023-01-23

Locations

1 site across 1 country: United States