NCT04222699

Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators propose to study the microbiome of the nose, throat and three skin sites in a population without current exposure to the healthcare environment: 80 community dwelling adults. We will characterize the microbial communities in these body sites (nose, throat, perirectal and three skin sites) over time using culture-independent techniques. The investigators will then "decolonize" the subjects. Subjects will receive intranasal mupirocin and topical chlorhexidine. The investigators will then compare the microbial communities at baseline and after decolonization within individuals. Our overall hypothesis is that the microbial composition of these sites and the response to decolonization is influenced by the healthcare environment and that decolonization leads to re-colonization with an increasing proportion of Gram-negative bacilli.

Conditions

• Human Microbiome

Interventions

Type	Name	Description
DRUG	Mupirocin calcium ointment, 2%	Mupirocin nasal ointment is used to treat or prevent infections in the nose due to certain strains of Staphylococcus aureus bacteria. This medicine works by killing bacteria or preventing their growth.
DRUG	Topical Chlorhexidine, 4%	Chlorhexidine is an antiseptic that fights bacteria. Topical chlorhexidine is used to clean the skin to prevent infection that may be caused by surgery, injection, or skin injury.

Timeline

• Start date: 2012-09-18
• Primary completion: 2014-11-18
• Completion: 2014-11-18
• First posted: 2020-01-10
• Last updated: 2020-04-14
• Results posted: 2020-04-14

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study