NCT04220736

Early Prediction of QFR in STEMI-Pharmaco-invasice

EARLY Microvascular Dysfunction Prediction Using Quantitative Flow Ratio in ST-segment Elevation MYOcardial Infarction Patients With Pharmaco-Invasive Strategy (EARLY-MYO-QFR PI)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.

Detailed description

Microvascular dysfunction (MVD) is a serious complication of PCI, which happens frequently after STEMI and always correlates with a poor prognosis. However, precise and simplified assessment of MVD is difficult, especially in the acute phase of STEMI patients. Resent studies suggested that FFR could be overestimated when MVD exists. But whether the overestimated value of FFR caused by CMR defined MVO could reflect microcirculation function is still unclear. This study is a retrospective study using STEMI patients who underwent pharmaco-invasive strategy as the population. Contrast-enhanced CMR was performed 5 days after PCI as the reference standard.

Conditions

• ST Segment Elevation Myocardial Infarction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Computation of quantitative flow ratio	Computation of QFR was performed offline, using AngioPlus system(Pluse medical imaging technology, Shanghai, China). In the first step, 2 diagnostic angiographic projections before PCI, at least 25° apart, were selected and 3D reconstruction of the interrogated vessel without its side branches was performed. Then, the software computed the QFR.

Timeline

• Start date: 2018-01-01
• Primary completion: 2020-07-01
• Completion: 2020-07-25
• First posted: 2020-01-07
• Last updated: 2020-04-10

Locations

1 site across 1 country: China