NCT04219787

Different Limb Lengths in Gastric Bypass Surgery

Swiss Multicenter Randomized Controlled Trial on Different Limb Lengths in Gastric Bypass Surgery

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 800 (estimated)
• Sponsor: Clarunis - Universitäres Bauchzentrum Basel · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of co-morbidities in the majority of patients. One of the most frequently performed operations is the laparoscopic proximal Roux-en-Y gastric bypass (LRYGB). There is still lack of knowledge why some patients respond much better than others to an identically performed procedure. Therefore, a number of variations of this operation have been introduced over the past 50 years. Increasing the length of small bowel being bypassed has the potential to improve the effect of the operation but buries the risk of nutrient deficiencies. The metabolic effect of LRYGB occurs, in part, independently of weight loss. The mechanisms underlying metabolic improvement through metabolic surgery are not yet fully understood.

Conditions

• Obesity, Morbid
• Diabetes Mellitus, Type 2
• Hypertension
• Dyslipidemias
• Sleep Apnea

Interventions

Type	Name	Description
PROCEDURE	Long BPL LRYGB	LRYGB with an 180 cm BPL and an AL of 80 cm.
PROCEDURE	Short BPL LRYGB	The second group will receive a standard LRYGB with a 80 cm BPL and a 180 cm long AL.

Timeline

• Start date: 2020-06-01
• Primary completion: 2028-11-30
• Completion: 2028-11-30
• First posted: 2020-01-07
• Last updated: 2023-11-13

Locations

1 site across 1 country: Switzerland