Clinical Trials Directory

Trials / Recruiting

RecruitingNCT04216732

Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management

Utilization of the Natural History of Medullary Thyroid Carcinoma to Inform Advanced Disease Management

Status
Recruiting
Phase
—
Study type
Observational
Enrollment
2,030 (estimated)
Sponsor
M.D. Anderson Cancer Center · Academic / Other
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understanding disease management. The goal of this study is to learn about how medullary thyroid cancer develops and progresses.

Detailed description

PRIMARY OBJECTIVES: I. To describe the natural history of medullary thyroid cancer (MTC) using a comprehensive battery of demographic, clinical, pathologic, and genotypic variables collected in our existing multi-institutional patient registry. Ia. To describe the demographic, clinical, pathologic, and genotypic variables associated with each phase of disease. Ib. To identify those variables which are predictors of progression to the most advanced phases of disease that require small molecule therapy, including commercially approved and experimental agents. II. To characterize patients' experience with the different phases of MTC through a systematic evaluation of patient-reported outcomes (PROs). IIa. To describe clinical, psychosocial, economic, and physical well-being variables and the subsequent impact on quality of life associated with each phase of disease. IIb. To evaluate longitudinal changes in clinical, psychosocial, economic, and physical well-being variables between and within all phases of MTC, and the subsequent impact they have on quality of life. III. To evaluate the association of selected biometric and patient-reported outcomes on adherence, change, and discontinuation of approved targeted therapies and drugs being tested within clinical trial. OUTLINE: AIM I \& II: Patients complete questionnaires over 10-40 minutes 2-4 times per year about health and how finances and quality of life effect experience with disease. AIM III: Patients complete a questionnaire over 2 minutes and undergo blood pressure measurements every day for up to 12 weeks. The questionnaire data gets paired with the collected medical record history that is maintained in the Registry.

Conditions

Interventions

TypeNameDescription
OTHERBlood Pressure MeasurementUndergo blood pressure measurement
OTHERQuestionnaire AdministrationComplete questionnaires

Timeline

Start date
2020-01-10
Primary completion
2026-09-01
Completion
2026-09-01
First posted
2020-01-03
Last updated
2026-03-05

Locations

2 sites across 1 country: United States

Source: ClinicalTrials.gov record NCT04216732. Inclusion in this directory is not an endorsement.