NCT04216537

Survival Significance of Molecular Pathology and Genetic Variation in Brain Gliomas

Survival Significance and Clinical Characteristics of Molecular Pathology and Genetic Variation in Brain Gliomas

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: The First Affiliated Hospital of Zhengzhou University · Academic / Other
• Sex: All
• Age: 1 Year – 95 Years
• Healthy volunteers: Not accepted

Summary

This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Detailed description

Precise classification based on molecular and genetic biomarkers/subgroups for gliomas is challenging. This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology (1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations, etc) and genetic data (Whole exome sequencing, RNA sequencing, proteomics, etc). This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Conditions

• Glioma
• Molecular Sequence Variation
• Genetic Change

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Glioma groups based on molecular pathology or genetic variation	Patients with newly diagnosed glioma that receive tumor resection

Timeline

• Start date: 2018-01-01
• Primary completion: 2025-01-01
• Completion: 2025-06-01
• First posted: 2020-01-02
• Last updated: 2021-02-08

Locations

1 site across 1 country: China