NCT04216394

Anticoagulation in Emergency General Surgery

Anticoagulation in Emergency General Surgery: Who Bleeds More? The ACES Trial

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 4 (actual)
• Sponsor: Methodist Health System · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

While DOACs are increasing in use in the EGS patient population, the risk of bleeding and the reversal of these agents to reduce hemorrhage is still evolving. Given the paucity of data regarding the impact of DOACs in this patient population, it becomes empiric to identify bleeding patterns and outcomes in the EGS population taking DOACs. We hypothesize that patients taking a DOAC will have a higher bleeding incidence and need for an unplanned intervention secondary to hemorrhage in EGS patients undergoing an urgent or emergent operation when compared to patients taking warfarin and antiplatelets.

Detailed description

Emergency general surgery (EGS) represents illnesses of diverse pathology with urgent/emergent treatment needs being the common denominator.A characteristic feature of EGS is its limitation in patient preparation. It is difficult and often impossible to eliminate certain patient dependent factors to reduce the operative risk. It has been reported that the annual case rate in the EGS population is (1,290 per 100,000) higher than the sum of all cancer diagnoses. The EGS burden is substantial and continues to increase. The elderly patient population represents 48% of the overall EGS population. With the increase in the prevalence of atherosclerotic disease in the elderly there has been an increase in the use of antiplatelets and anticoagulants.

Conditions

• Emergency General Surgery

Interventions

Type	Name	Description
PROCEDURE	Emergency general surgery	multidisciplinary surgery performed for traumatic and non-traumatic acute conditions during the same admission in the hospital.

Timeline

• Start date: 2019-10-31
• Primary completion: 2020-11-13
• Completion: 2020-11-13
• First posted: 2020-01-02
• Last updated: 2026-03-27

Locations

1 site across 1 country: United States