NCT04216004

Anti-Inflammatory Milk Matrix

Dairy Food Consumption and Its Effects on Inflammation and the Postprandial Regulation of Muscle Protein Synthesis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: All
• Age: 40 Years – 59 Years
• Healthy volunteers: Accepted

Summary

Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction. As such, obesity programs should not only focus on weight loss, but muscle metabolic health. Dairy nutrients have anti-inflammatory and anabolic properties, but mostly evaluated in isolation and/or pre-clinical designs. Also, it is unknown if the circulating benefits extend to the muscle. We hypothesize that dairy full-fat milk will improve these obesity characteristics.

Conditions

• Obesity
• Skeletal Muscle
• Inflammation

Interventions

Type	Name	Description
BEHAVIORAL	Controlled-Feeding Intervention	All energy-containing food and beverages will be provided for 1-week as a controlled-feeding study.
DIETARY_SUPPLEMENT	Non-dairy beverage	Isolated amino acid, fatty acid, and monosaccharide beverage matched to the macronutrient content of 8 fl oz whole milk.
OTHER	Full-fat milk	3 daily servings (cup-eq) of full-fat (3.25%) commercial cow's milk.
OTHER	Fat-free milk	3 daily servings (cup-eq) of fat-free (0%) commercial cow's milk.

Timeline

• Start date: 2020-02-14
• Primary completion: 2023-12-01
• Completion: 2024-03-01
• First posted: 2020-01-02
• Last updated: 2023-05-09

Locations

1 site across 1 country: United States