NCT04215770

Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin

Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin in Children With Severe Tonsillitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 310 (actual)
• Sponsor: Combined Military Hospital, Pakistan · Academic / Other
• Sex: All
• Age: 5 Years – 15 Years
• Healthy volunteers: Not accepted

Summary

To compare intravenous Co-amoxiclav versus Benzyl penicillin in children with severe streptococcal tonsillitis in terms of efficacy, safety and cost effectiveness.

Detailed description

Efficacy was measured through improvement (decrease in fever, settling lymphadenopathy and disappearance of tonsillar exudate) in Centor Criteria score on daily basis. Improvement i.e reduction in Centor Criteria score was recorded for all children till full recovery. Safety was measured by frequency of hypersensitivity reactions or severe side effects of antibiotics necessitating stoppage of the drug. All the children in both Groups were given test dose of the antibiotic before giving full dose of antibiotic prescribed. Cost effectiveness was compared in terms of total cost of injections (Co-amoxiclav versus Benzyl penicillin) which were administered to children in both groups.

Conditions

• Tonsillitis Streptococcal

Interventions

Type	Name	Description
DRUG	inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day	Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness

Timeline

• Start date: 2018-01-01
• Primary completion: 2019-11-01
• Completion: 2019-11-01
• First posted: 2020-01-02
• Last updated: 2020-01-03

Locations

1 site across 1 country: Pakistan