NCT04215237

How Atorvastatin Affects the Gut Flora and Metabolomics?

A Clinical Observational Trail on Atorvastatin Regulates Intestinal Flora and Metabolomics.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: First Affiliated Hospital Xi'an Jiaotong University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Recent studies suggest that gut microbiome, the microbial community in the intestine, may directly and indirectly influence the progression of atherosclerosis. The imbalance of gut microbiome may directly promote the formation of atherosclerotic plaques by promoting the inflammatory reaction and oxidative stress affecting vascular endothelial function and increasing platelet activity. Meanwhile, it can indirectly increase the risk of atherosclerosis by enhance insulin resistance, reducing the production of bile acids and raising serum LDL-C and angiotensin levels. As shown in these researches, gut microbiome, acting as a bridge between metabolism, energy and inflammatory responses, may play an important role in cardiovascular diseases, and we believe that the interaction between microbiome and host should be considered in the ASCVD study.

Conditions

• Atherosclerotic Cardiovascular Disease

Interventions

Type	Name	Description
DRUG	Atorvastatin 20 Mg Oral Tablet	Atorvastatin 20mg oral once a day

Timeline

• Start date: 2017-11-13
• Primary completion: 2020-06-01
• Completion: 2021-06-01
• First posted: 2020-01-02
• Last updated: 2020-01-02

Locations

2 sites across 1 country: China