NCT04211766

Fiber and Fish Oil Supplements for the Prevention of Colorectal Cancer

Diet and the Colonic Exfoliome: A Novel, Non-Invasive Approach to Testing Interventions in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Fred Hutchinson Cancer Center · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This trial studies how fiber and fish oil supplements affect the metabolism and activities of colon cells in healthy individuals. Diet is an important risk factor for colorectal cancer, and several dietary components important in colorectal cancer prevention are modified by gut microbial metabolism. Giving fiber and fish oil supplements may inhibit the growth of gut cells and ultimately reduce risk of colorectal cancer.

Detailed description

Participants are randomized to receive two dietary interventions in assigned random order. They either receive the dietary fiber supplement and fish oil supplement orally (PO) daily or they receive a fiber control and corn oil supplement daily for 30 days during the first intervention period. Then they enter a washout period for 60 days when they do not receive any treatment. After that they complete the second intervention period during which they receive the other intervention.

Conditions

• Healthy Subject

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Dietary Fiber	Given fiber supplement
DIETARY_SUPPLEMENT	Fish Oil	Given fish oil supplement
OTHER	Comparator	Given fiber supplement placebo
OTHER	Comparator	Given fish oil supplement placebo (corn oil)

Timeline

• Start date: 2021-01-05
• Primary completion: 2022-08-16
• Completion: 2022-08-16
• First posted: 2019-12-26
• Last updated: 2024-09-27
• Results posted: 2023-10-17

Locations

1 site across 1 country: United States