Trials / Not Yet Recruiting
Not Yet RecruitingNCT04211636
Autoimmunity And Immune Deficiency After Spinal Cord Injury: Association With Rehabilitation Outcomes
Maladaptive Systemic Immune Response After Spinal Cord Injury: Humoral Post-traumatic Autoimmunity Against Central and Peripheral Nervous System Antigens in Association With Neurogenous Immune Depression as a Confounder of Rehabilitation
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 81 (estimated)
- Sponsor
- Marcel Kopp, MD · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- —
Summary
The SCIentinel-prolong study systematically analyzes humoral autoantibody responses and thier interaction with post-spinal cord injury (SCI) immune-deficiency and infections as well as their association with the clinical course of rehabilitation. Therefore, molecular and immunological tests in blood and cerebrospinal fluid specimen are combined with clinical outcomes ranging from neurological function, neuropathic pain and spasticity to walking tests and measures of independence in daily living within the first year after SCI. Including a control group with participants suffering from vertebral fractures without SCI allows to differentiate between neurological and general injury and treatment effects.
Conditions
Timeline
- Start date
- 2023-10-01
- Primary completion
- 2025-10-01
- Completion
- 2026-04-01
- First posted
- 2019-12-26
- Last updated
- 2023-02-08
Source: ClinicalTrials.gov record NCT04211636. Inclusion in this directory is not an endorsement.