NCT04211246

Oxygen Reserve Index to Reduce Hyperoxia

Efficacy of Oxygen Reserve Index (ORI) to Reduce Hyperoxia in Major Abdominal Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Eunah Cho, MD · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. Hyperoxia is very common in general anesthesia settings. Even though there are concerns in using excessive oxygen during general anesthesia, the optimal fraction of inspired oxygen (FiO2) for general anesthesia is not well studied. The oxygen reserve index (ORI) is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORI that it might be helpful to reduce hyperoxia in critically ill patients in the intensive care unit, as well as in general anesthesia. The aim of this study is to evaluate efficacy of oxygen reserve index to reduce hyperoxemia in major abdominal surgery.

Conditions

• Hyperoxemia

Interventions

Type	Name	Description
PROCEDURE	Titration of fraction of inspired oxygen (FiO2) guided by SpO2	Titration of fraction of inspired oxygen (FiO2) guided by SpO2
PROCEDURE	Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2	Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2

Timeline

• Start date: 2020-10-07
• Primary completion: 2022-03-28
• Completion: 2022-03-28
• First posted: 2019-12-26
• Last updated: 2022-03-31

Locations

1 site across 1 country: South Korea