NCT04210453

The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 264 (estimated)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased. The anti-inflammatory and anti-oxidant effects of vitamin C and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery. In this study, investigators investigate the effect of intravenous vitamin C on the incidence of acute renal injury after valvular heart surgery.

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	Vitamin C	Participants in "Vitamin C group" are administered IV vitamin C diluted in 100 cc normal saline 1 day before surgery, at rewarming during surgery, 3 hours after surgery, and every 6 hours thereafter until postoperative 24 hours.
DRUG	Control (Normal saline)	Participants in "Control group" are administered IV 100cc normal saline at the same timepoint as above.

Timeline

• Start date: 2020-03-24
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2019-12-24
• Last updated: 2020-03-26

Locations

1 site across 1 country: South Korea