NCT04208802

Effect of Smoking on Saliva Composition and the Development of Dental Erosion

Effect of Smoking on Saliva Composition and the Development of Dental Erosion - an In-situ Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: University of Göttingen · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion. Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured. Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.

Conditions

• Dental Erosion

Interventions

Type	Name	Description
OTHER	Use of fluoridated toothpaste	Use of fluoridated toothpaste
OTHER	Wearing of an intraoral device with bovine tooth samples	Wearing of an intraoral device with bovine tooth samples
OTHER	Wearing of an intraoral device with resin samples	Wearing of an intraoral device with resin samples

Timeline

• Start date: 2020-09-24
• Primary completion: 2022-07-29
• Completion: 2022-07-29
• First posted: 2019-12-23
• Last updated: 2026-01-27

Locations

1 site across 1 country: Germany