NCT04207450

Effect of Glutaraldehyde on Dentin Hypersensitivity After Non-surgical Periodontal Treatment

Effect of Glutaraldehyde on Dentin Hypersensitivity After Non-surgical Periodontal Treatment: a Triple-blind Randomized Clinical Trial.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Universidade Federal do Para · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This randomized, placebo-controlled, triple-blind trial aims to evaluate the effect of glutaraldehyde associated or not with 37% phosphoric acid conditioning on dentin hypersensitivity reduction after non-surgical periodontal treatment, and its durability after 15 and 30 days. desensitizing treatment. Additionally, investigate the impact of these treatments on health-related quality of life. The investigators selected patients who, after scraping and planing procedures, presented at least 2 teeth meeting the following inclusion criteria: presence of gingival recession without or with a periodontal pocket up to 5mm probing depth, which presented painful sensitivity response to tactile stimulus. and evaporative. Subjects were randomized into 3 groups: Placebo Group (GP) - Placebo Gel application followed by Placebo solution (distilled water); GPG- Placebo Gel application followed by application 5% aqueous glutaraldehyde solution; GSG - Application of 37% phosphoric acid followed by 5% aqueous glutaraldehyde solution. The sensitivity of the dental elements was evaluated by pain stimuli (tactile and evaporative) with the aid of a Visual Analog Scale (VAS). A questionnaire was applied to patients with the objective of capturing psychosocial experiences, prior to treatment and one month after its completion, to assess the impact of desensitizing treatment on health-related quality of life. Data will be collected and appropriate statistical tests will be applied.

Conditions

• Dentin Sensitivity

Interventions

Type	Name	Description
OTHER	Placebo gel	Placebo gel application followed by placebo solution application (distilled water)
OTHER	Placebo Gel + 5% Glutaraldehyde Aqueous Solution	Placebo gel followed by 5% aqueous glutaraldehyde solution
OTHER	Phosphoric Acid 37% + Solução aquosa de glutaraldeído a 5%	37% phosphoric acid application followed by 5% aqueous glutaraldehyde solution

Timeline

• Start date: 2019-03-15
• Primary completion: 2019-11-29
• Completion: 2019-12-13
• First posted: 2019-12-20
• Last updated: 2020-04-21

Locations

1 site across 1 country: Brazil