NCT04205929

Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users

Treatment of Unfavorable Bleeding Patterns in Contraceptive Implant Users: a Randomized Clinical Trial of Curcumin

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: Female
• Age: 15 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The investigators plan to study the effects of curcumin, the active ingredient in the spice turmeric, on the irregular bleeding experienced by women who use the contraceptive implant.

Detailed description

The investigators are proposing a randomized, double blind placebo-controlled clinical trial over a 30-day reference period for treatment of women experiencing bothersome bleeding while using the etonogestrel (ENG) contraceptive implant. The primary outcome of the study will be the total number of amenorrhea days in a 30-day reference period. The study has a number of secondary outcomes (see study objectives) focused around the efficacy of oral curcumin to stop bleeding/spotting and for how long.

Conditions

• Bleeding
• Implants
• Breakthrough Bleeding

Interventions

Type	Name	Description
DRUG	Placebo	Placebo (oral) once daily for 30 days. Treatment to be started after 3 consecutive days of bleeding
DRUG	Curcumin	Curcumin 600 mg (oral) once daily for 30 days. Treatment to be started after 3 consecutive days of bleeding

Timeline

• Start date: 2020-04-15
• Primary completion: 2022-11-05
• Completion: 2023-08-01
• First posted: 2019-12-20
• Last updated: 2024-07-03
• Results posted: 2024-07-03

Locations

1 site across 1 country: United States