Trials / Completed
CompletedNCT04203615
Effect of Noninvasive Brain Stimulation on Hypokinetic Dysarthria in Parkinson's Disease
Effect of Noninvasive Brain Stimulation on Hypokinetic Dysarthria and Brain Plasticity in Parkinson's Disease
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 39 (actual)
- Sponsor
- Masaryk University · Academic / Other
- Sex
- All
- Age
- 50 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD) patients and responds only partially to pharmacotherapy and surgery. The investigators will explore long-term effects of repetitive transcranial magnetic stimulation (rTMS) applied over right superior temporal gyrus, brain area known to be engaged in the feedback control of voiced speech. The project results will allow for the identification of potential therapeutic effects of rTMS as a tool that could contribute to the speech therapy of HD in PD patients. The results will also enhance our understanding of brain mechanisms underlying specific long-term effects of rTMS.
Detailed description
A two parallel group, randomized, placebo controlled design will be used. Twenty PD patients will be stimulated in a two weeks long therapeutical sessions (10 sessions). Other twenty PD patients will be stimulated with the same protocol using sham stimulation. An MRI protocol consisting of T1, EPI BOLD, and DTI (diffusion tensor imaging) sequences and speech evaluation (acoustic signal processing and 3F test) will be performed prior to and after 10 days of rTMS and then repeated after 4, 8 and 12 weeks.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Transcranial magnetic stimulation- sham rTMS | Transcranial magnetic stimulation- sham figure-eight coil will be used for stimulation. This sham coil will generate only clicking noise and will not generate any magnetic field. |
| DEVICE | Transcranial magnetic stimulation- real rTMS | Transcranial magnetic stimulation- figure-eight coil will be used for stimulation. 1 Hz stimulation, 100% of Resting Motor Threshold will be used. |
Timeline
- Start date
- 2019-07-01
- Primary completion
- 2020-01-30
- Completion
- 2020-01-30
- First posted
- 2019-12-18
- Last updated
- 2020-09-02
Locations
1 site across 1 country: Czechia
Source: ClinicalTrials.gov record NCT04203615. Inclusion in this directory is not an endorsement.