NCT04195529

Genetic Polymorphisms Associated With Vertebral Osteochondrosis

Evaluation of Polymorphisms in the Vitamin D Receptor and Involved in Inflammation Associated With Vertebral Osteochondrosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The present study is proposed for the identification of phenotype, biochemical and genetic markers in adult symptomatic spinal osteochondrosis to promote the early diagnosis of this pathological condition and to establish possible therapeutic targets that favor a conservative approach aimed at treating patients.

Detailed description

The primary outcome is to determine the association between specific phenotypic characteristics of osteochondrosis, in particular linked to osteo-cartilaginous degeneration, with the identified vitamin D receptor genotypes. The secondary outcomes are to evaluate the circulating levels of the osteo-cartilage degradation markers, of the vitamin D and to evaluate the association of the osteochondrosis phenotype with variants in genes involved in inflammatory processes.

Conditions

• Spinal Osteochondrosis

Interventions

Type	Name	Description
GENETIC	presence of genetic variants	identification of the presence of genetic variants

Timeline

• Start date: 2019-11-19
• Primary completion: 2020-12-01
• Completion: 2022-12-01
• First posted: 2019-12-12
• Last updated: 2019-12-12

Locations

1 site across 1 country: Italy