NCT04191226

Genetic Mutation in Recurrent Cervical Cancer

Overall Perspective on the Characteristics of Genetic Mutation in Recurrent Cervical Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Lei Li · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Little is known about the characteristics of genetic mutation in recurrent cervical cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy and immunotherapy.

Conditions

• Recurrent Cervical Cancer
• Nucleotide Variant
• Copy Number Variation
• Insertion-deletion Variation
• Genomic Structural Variation
• Total Mutation Burden
• Microsatellite Instability
• PD-1
• PD-L1

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Multi-gene panel testing	A multi-gene panel, which consists of more than 500 hundred genes will be provided for mutation analysis

Timeline

• Start date: 2019-12-19
• Primary completion: 2022-01-01
• Completion: 2023-01-01
• First posted: 2019-12-09
• Last updated: 2019-12-20

Locations

1 site across 1 country: China