NCT04191174

Ventilation Heterogeneity Prior to Lung Resection

Prevalence and Clinical Relevance of Ventilation Heterogeneity and Luminal Cellular Inflammation in Lung Cancer Patients Prior to Lung Resection

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 115 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
OTHER	Hyperpolarized 129Xe MRI	Hyperpolarized 129Xe MRI to evaluate ventilation heterogeneity
OTHER	Technegas V SPECT	Technegas V SPECT to evaluate ventilation heterogeneity
OTHER	Sputum Induction	Sputum induction to evaluate luminal cellular inflammation

Timeline

• Start date: 2020-01-06
• Primary completion: 2024-06-01
• Completion: 2024-12-01
• First posted: 2019-12-09
• Last updated: 2024-01-05

Locations

1 site across 1 country: Canada