NCT04190888

Sickle Cell Uric Acid (SCUA) - Cohort Repository

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 78 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 5 Years – 29 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as to collect and store samples and information about people with Sickle Cell Disease.

Detailed description

Sickle Cell Disease causes kidney injury over time, but it is not clear why some individuals have very significant chronic kidney disease and why some do not. The purpose of this research is to study whether having high levels of 'uric acid,' which is a naturally occurring molecule in the body that may increase kidney injury and systemic inflammation, accelerates the progression of chronic kidney disease over time. Researchers will measure the number of participants that have high uric acid levels at the beginning of the study, as well as the number of participants that develop new high levels throughout the study. The study will also try to determine what causes the high uric acid levels in some patients but not others. The results of this study could help understand kidney injury and uric acid in sickle cell disease better.

Conditions

• Chronic Kidney Diseases
• Sickle Cell Disease

Interventions

Type	Name	Description
OTHER	No intervention	No intervention - observational study

Timeline

• Start date: 2019-07-01
• Primary completion: 2021-12-31
• Completion: 2021-12-31
• First posted: 2019-12-09
• Last updated: 2022-02-04

Locations

1 site across 1 country: United States